With European football, a whole group stage of it, the Carabao (still not sure what that is, some kind of drink?) Cup has even less importance than usual. On the other hand, with few injuries even a heavily rotated line up should be reasonably strong, and we don't want to lose our still good vibes with a thumping from what will presumably be a pretty big name Man United line up, considering their options.
I would go
Areola
Fredericks Diop Dawson Zouma Masuaku
Noble Kral
Vlasic Lanzini
Antonio/Yarmalenko
Five at the back makes a lot of sense to me if we're rotating full backs and centre mid. Centre forward I'm leaving because it really depends on Antonio's physical condition. Yarmalenko started strongly off the bench, but then quickly irritated Moyes, and I really don't know if he's comfortable in that 9 position.
Honestly I think this will be a tricky game for us, but hopefully debut starts for Areola and Kral, and a chance for Vlasic to bed himself further into the team.