It's over 4 days between the Brentford game finishing and this ko. Not too worried about fatigue with that much time and adrenaline. Will need to use subs cleverly though.
The other way around it's effectively 2 and a half days from Lyon finishing and the 2pm KO for Brentford, much harder.
Also as someone has mentioned before, Brentford had a week to prepare for us, we had 2 days. Lyon are in the same boat as us and we only played them last week so fairly prepared for it.